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Mathematical Framework for Human Equivalent Dose The human equivalent dose (HED) formula is: HED (mg/kg) = Animal dose (mg/kg) (Animal Km / Human Km) Standard Km constants used in pharmacological scaling are: Rat Km = 6 Human Km = 37 To illustrate: If a rat study administers 10 mcg/kg, convert micrograms to milligrams: 10 mcg = 0.01 mg HED = 0.01 (6 / 37) HED 0.00162 mg/kg HED 1.62 mcg/kg For a 70 kg individual: 70 1.62 mcg 113 mcg This represents a mathematically scaled equivalent exposurenot a prescription

Conclusion In summary, to the best knowledge, the present study is the first to demonstrated that intravenous L-carnitine administration boosted the effects of modified fasting therapy on weight loss and alleviated metabolic abnormalities

Results also revealed that this amino acid can prevent exercise-induced muscle damage based on the reduced efflux of inflammatory enzymes and reduced oxidative stress during exercise

Jeonghan Kim, R